APCprotein

The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations ...

2013年3月1日 — The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It ...

由 K Aoki 著作 · 2007 · 被引用 629 次 — The APC gene product is a 312 kDa protein that has multiple domains, through which it binds to various proteins, including beta-catenin, axin, ...

由 MC Faux 著作 · 2004 · 被引用 159 次 — Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. J Cell Sci. 2004 Jan 26;117(Pt 3):427 ...

由 RL White 著作 · 1997 · 被引用 16 次 — In the case of colon cancer, we were fortunate in identifying an inherited tumor suppressor gene, the APC gene, that plays a major etiologic role in both the ...

4 天前 — This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes ...

由 W Hankey 著作 · 2018 · 被引用 146 次 — By negatively regulating canonical WNT signaling, APC counteracts proliferation, promotes differentiation, facilitates apoptosis and suppresses invasion and ...

由 Y Mimori-Kiyosue 著作 · 2000 · 被引用 347 次 — APC protein is involved in regulation of the stability of β-catenin, and mutations in the APC gene result in carcinogenesis by stabilizing β-catenin followed by ...

The adenomatous polyposis coli (APC) protein is a component of the Wnt/β-catenin signaling pathway that negatively regulates cell growth. APC complexes with ...